These highlights don't contain all the knowledge necessary to use Depakote securely and efficiently. See entire prescribing details for Depakote.
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Treat the manic period of bipolar dysfunction. A manic episode can be a time frame in which your mood is amazingly sturdy. This will likely contain an elevated or an irritated temper.
If a dose is missed it ought to be taken as quickly as possible, Unless of course it is nearly time for another dose. If a dose is skipped, the affected individual shouldn't double another dose.
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Suitable scientific studies carried out so far haven't demonstrated geriatric-certain issues that could Restrict the usefulness of divalproex sodium inside the aged.
Standard specifics of the Secure and powerful use of Depakote Medicines are sometimes prescribed for uses aside from People stated inside a Medication Guide. Never use Depakote for your issue for which it wasn't prescribed.
There are stories of acute or subacute encephalopathy while in the absence of elevated ammonia stages, elevated valproate stages, or neuroimaging changes. The encephalopathy reversed partly or thoroughly immediately after valproate discontinuation.
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In some instances, liver harm might proceed Regardless that the medicine is stopped. Your healthcare supplier will do blood assessments to examine your liver ahead of And through cure with DEPAKOTE.
Since clients had been being titrated off A different antiepilepsy drug through the first part of the demo, it's impossible, in several circumstances, to ascertain no matter whether the subsequent adverse reactions may be ascribed to Depakote by yourself, or the combination of valproate and also other antiepilepsy drugs.
Elimination: The primary route of elimination for VPA is through the kidneys, involving the excretion of its metabolites by using urine. About thirty% to 50% from the administered dose of VPA is excreted unchanged in the urine, whereas The remainder is excreted as metabolites. Various variables, which includes dosages, age, gender, renal functions, genetic polymorphisms, and drug interactions, impact the elimination price of VPA throughout the check here physique.